 This study investigated the presence of antibodies against the tumor suppressor gene P53 in serum samples of patients with oral squamous cell carcinoma and oral potentially malignant disorders compared to healthy individuals. The results showed that 98.3% of the patients with oral squamous cell carcinoma had antibodies present in their serum, while 96.6% of those with oral potentially malignant disorders also had antibodies. In contrast, only 33.3% of the healthy controls had antibodies present. This suggests that antibody presence may be a marker for these conditions and could serve as a diagnostic or prognostic biomarker. This article was authored by Abbas Salim Khan, Sejad Ahmad, Zahorullah, and others.