 The researchers discovered that PML nuclear bodies play two important roles in the cell. Firstly, they act as storage centers for the H3.3 histone chaperone complex, which helps to maintain the correct amount of H3.3 in the nucleus. Secondly, they also serve as a hub for the regulation of gene expression, specifically for interferon-stimulated genes, ISGs. This is achieved by the interaction between PML and the DAXX higher protein complex, which allows for the accumulation of H3.3 at the transcriptional ends of ISGs. Without these interactions, the proper regulation of ISGs would not be possible. This article was authored by Constance Kleiwecht, Florent Bresak, Kolein Sir, and others.