 Next-generation sequencing, NGS, technologies have revolutionized biological research, allowing scientists to quickly and cost-effectively obtain large amounts of genetic data. The most popular NGS platforms include the solid ion-torrent PGM from Life Sciences, the genome analyzer HiSEC-2000 MISEC from Illumina, and the GSFLX Titanium GS Junior from Roche. BGI, which owns the largest sequencing capacity in the world, operates several of these platforms, including 137 HiSEC-2000, 27 solid, one ion-torrent PGM, one MISEC, and one 454 sequences. This paper reviews the technologies behind these platforms, analyzes first-hand data from extensive experience, and summarizes the advantages and specifics associated with each platform. Finally, applications of NGS are discussed. This article was authored by Lin Liu, Yinhu Li, Xiliang Li, and others.