 Oxidants are produced naturally by all cells during normal metabolism, and when kept within safe limits, they serve as intracellular signaling molecules for complex processes. However, if not controlled properly, these oxidants can cause damage to cells and tissues, leading to conditions such as diabetes and heart disease. In this study, researchers investigated the serum concentration of heat shock protein 70, HSP70, in young, non-obese but overweight men, and found that it was significantly higher than in lean men. They also noted that there was a strong correlation between the concentration of HSP70 and the insulin level and HOMI-R index, which measures insulin resistance. This suggests that measuring the extracellular concentration of HSP70 could be an important indicator in disorders of glucose homeostasis. This article was authored by Anna Lubkowska, Violeta Dudzinska, and Waldemar Pluta.