 Nanosymes are a promising new class of antimicrobial agents, but they have limitations when it comes to treating infections at deeper levels. This study proposes a novel approach using copper nanoparticles embedded in a silk fibroin matrix to create a more effective solution. By adjusting the number of nitrogen atoms surrounding the copper particles, researchers were able to increase the activity of the nanoparticles, allowing them to be used for deeper infections. Additionally, the nanoparticles can absorb light in the near-infrared spectrum, which allows them to penetrate deeper into the body and kill bacteria. In tests, the nanoparticles were found to be highly effective against drug-resistant bacteria and could potentially be used as a powerful tool in the fight against infection. This article was authored by Jiasheng Bai, Yonghai Feng, Wenming Li, and others.