 The study investigates the effects of glucocorticoid treated dendritic cells on antitumor immune responses in OT1 or rag of mice, expressing a transgenic TCR in CD8 plus T cells. The results show that immunization with CPG and peptid-treated DCS protected against tumor growth by activating NK cell response, while GC-treated DCS increased the numbers of immature Mac1 plus CD27 NK cells, as well as Foxp3 plus and Illinois 10-secreting CD8 plus OT1 cells with suppressive properties. The study concludes that tollerogenic DCS modify antitumor immune response by suppressing NK cell activity and stimulating the formation of Illinois 10-secreting CD8 plus trex. This article was authored by Lying Chen, Muhammad Sharif Hasni, Mikhail John Dao, and others.