 This study investigated the role of TRAF5 in hepatocellular carcinoma, HCC. The results showed that TRAF5 deficiency induced necroptises in HCC cells, which was mediated by suppression of lymphotoxin beta receptor, LTBR, mediated nuclear factor Kappa B, NF Kappa B, signaling. Furthermore, TRAF5 deficiency also suppressed xenograft tumor growth, inhibited cell proliferation, and promoted tumor cell apoptosis. These findings suggest that TRAF5 may be a potential target for treating HCC. This article was authored by Guilin Wu, Fongping Wu, Yang Qingzhou, and others.