 Reactive oxygen species, ROS, play a vital role in the progression of cardiovascular diseases. This review focuses on pathways behind the production of ROS, its involvement in intracellular signalling cascades leading to several cardiovascular disorders, endothelial dysfunction, ischemia reperfusion, and atherosclerosis. This article was authored by Nisha Panth, Keshav Raj portal, and Kalpana Parajuli.