 In this study, researchers examined the diagnostic yield of exome sequencing, ES, in a cohort of predominantly U.S., an underrepresented minority, UIM, pediatric, and prenatal patients suspected to have a genetic disorder. They found that the diagnostic yield was 23.8% overall, with a significantly higher diagnostic rate in pediatric, 26.7%, compared to prenatal patients, 19%. Additionally, they found no significant difference in the diagnostic yield between UIM and non-UIM patients, or between patients with U.S. status and those without U.S. status. This suggests that ES can be used to identify clinically relevant variants in patients from diverse populations. This article was authored by Enslavatinik, Shannon Rigo, Neri Sahin Hodoglujil, and others.