 This study developed a new type of hydrogel material consisting of a combination of two natural polymers, chitosan and alginate, with the addition of a bioactive compound called cartogenin. This hydrogel was designed to be used as a scaffold for cartilage tissue engineering. It had favorable properties such as good mechanical strength, easy injectability, and long-term sustained release of cartogenin. Additionally, it promoted chondrogenic differentiation and improved the healing of articular cartilage defects. This article was authored by Chaoli, Yubalu, Tujuan Wang, and others.