 Then, drymers are polymeric architectures that have defined structures and versatility in drug delivery. They can entrap or conjugate high molecular weight hydrophilic hydrophobic entities through host-gist interactions and covalent bonding, respectively. Their high ratio of surface groups to molecular volume makes them a promising synthetic vector for gene delivery. Despite their extensive applications, then drymers have limited use in biological systems due to toxicity issues associated with them. Strategies for synthesis, drug delivery, targeting, gene delivery, and characterization techniques are discussed, along with approaches to alleviate toxicity problems. This article was authored by Kanika Madan, Sandeep Kumar, Neelam Punea, and others.