 The study investigated developmental changes in high-frequency oscillation, HFO, and modulation index, MI, a coupling measure between HFO and slow wave phase, using subdural EEG signals from 8251 non-epileptic electrode sites in 114 patients who achieved seizure control following receptive epilepsy surgery. The study found that occipital lobe had higher MI across all ages, with occipital MI increasing notably during early childhood. The cortical areas exhibiting MI co-growth were connected via the vertical occipital fasciculi and posterior callousal fibres. While occipital HFO rate showed no significant age association, the temporal, frontal, and parietal lobes exhibited an age-inversed HFO rate. The study also found that Zscore normalized MI and HFO rate were higher at seizure-onset versus non-epileptic electrode sites, and has publicly shared its intracranial EEG data to enable investigators to validate MI and HFO-centric presurgical evaluations to identify the epileptogenic zone. This article was authored by Kazuki Sakakura, Nooto Kuroda, Masaki Sonoda, and others. We are article.tv, links in the description below.