 The CREOEM structure of the DMIR ectodomain DILP5 complex reveals high homology between DMIR and HIR with DMIR binding three DILP5 molecules in a distinct arrangement, showing also DMIR specific features. This work supports evolutionary conservation of the IIS axis at the IR level and provides insight into an important model organism. This article was authored by Christina M. Viola, or Shulia Fritman, Hugh T. Jenkins, and others.