 Abstract type 2 diabetes mellitus, T2DM, is a chronic condition caused by impairment of insulin secretion and or insulin sensitivity. It is associated with genetic, metabolic, lifestyle and socio-demographic factors. Dietary lipids and lipid metabolism play a key role in T2DM while altered gut microbiota can also contribute to its development. Lipidomics, a novel parameter measured using holistic analytical techniques, has been found to be involved in the pathophysiology and progression of T2DM. Better understanding of the roles of dietary lipids and lipidomics in T2DM through gut microbiota interactions could lead to the development of new strategies for the prevention and treatment of T2DM. This article was authored by Doigu Agindis, Mehmet Arafisa, Iskaya Sildamir and others.