 This study examined the role of 25 enhancers in the development of cardiomyocytes. The researchers found that when these enhancers were oppressed, it led to delay transition from mid to late stage cardiomyocytes states. They also discovered that deletion of two specific enhancers mimicked the effects of epigenetic changes. This suggests that misregulation of these enhancers may be linked to cardiac defects in humans. This article was authored by Daniel A. Almondaris, Sean C. Goach, Anjana Sundarajan, and others.