 This study demonstrated the potential of using eye-tracking technology to measure the effects of serious games on autistic individuals. It was found that autistic individuals exhibited different gaze patterns when looking at faces expressing different emotions, suggesting that these patterns could be used as biomarkers to evaluate the effectiveness of serious games. Additionally, the study showed that prolonged sac-odd durations and short-of-fixation times for social-related facial emotion expressions were found in pre-adolescents and teenagers with autism, indicating that these atypical gaze patterns may be indicative of improved social and cognitive functioning during gameplay. This study suggests that eye-tracking technology can be used to measure the effects of serious games on autistic individuals, providing valuable insights into how serious games can be used to improve cognition and social skills. This article was authored by Yiling Qian, Chie Hsien Li, Yan Nian Chiu, and others.