 Polyethera thyrketone, peak, a chemically inert polymer, has been investigated for use in tissue engineering due to its mechanical properties and lack of adverse reactions when in contact with biological tissues. However, its bioinertness limits its potential for bone repair. In this study, researchers have developed a novel method for modifying peak surfaces with a peptide sequence designed to promote osteogenic differentiation of human osteoblasts. This peptide sequence, known as GBMP1-alpha, was successfully grafted onto peak surfaces via two different chemical methods. The resulting modified peak surfaces exhibited increased mineralization and gene expression of human osteoblasts compared to unmodified peak surfaces. Furthermore, these modified surfaces did not cause any cytotoxicity or affect cell viability. Overall, this study demonstrates the potential of peak surfaces modified with GBMP1-alpha for enhancing bone regeneration. This article was authored by Leonardo Cassari, Ange Simuner, Grazia Maria Lucia Massina, and others. We are article.tv, links in the description below.