 Neuroblastoma, NB, is a severe form of tumor that occurs mostly in young children and arises from nerve cells located in the abdomen or near the spine. Current treatments are not always effective and can lead to serious side effects that affect the quality of life of survivors. Pyrrhozoal-loaded cationic nanoparticles, CB1-HP7-N piece, have been shown to be effective against bacteria and may offer a promising alternative treatment option for NB. In vitro studies showed that CB1-HP7-N piece were highly cytotoxic to two NB cell lines, IMR32 and SHSY5Y, with IC50 values ranging from 0.43 to 0.54 muM. Furthermore, the nanoformulation of CB1-HP7-N piece was more potent than fennrenonide, an experimental retinoid derivative currently being tested in a phase III clinical trial. These findings suggest that CB1-HP7-N piece could be used as a potential therapeutic agent for treating NB. This article was authored by Gendalina Zuckery, Alessia Zorzoli, Danilo Merimpiatri, and others. We are article.tv, links in the description below.