 When it comes to otologous stem cell transplantation during the COVID-19 pandemic the general recommendation was to postpone this and to add some more induction regimens. So after easing the lockdown I think the auto transplant procedures in France and many other countries started again and patients were able to receive the auto transplant procedure of course we cannot exclude that some patient are asking well why shouldn't we skip this auto transplant procedure because of it is known impact in terms of mucositis, pain, diarrhea and need for hospitalization and I think this is a fair question and I believe the answer is the sort of direct communication, direct dialogue between the physician and an individual patient. The general rule is about you know resuming and delivering these auto transplant that were delayed but on a case per case basis things can be discussed depending on the patient features and characteristics but also depending on the disease features and the response to the therapy especially the induction regimens.