 Abstract metabolism is controlled by multiple regulatory mechanisms, such as allosteric control and transcriptional regulation of metabolic enzymes and transporters. In this study, researchers found that three-quarters of all metabolic genes are transcriptionally regulated in an nematode kinohubditis elegance. They also identified co-expressed metabolic pathways using gene expression data and the ICL1314 metabolic network model. Additionally, they developed a web application called Wormclust which allows users to search for specific genes and see how they relate to metabolic pathways. This study demonstrates the ubiquitous nature of transcriptional regulation of metabolism and provides a framework for future studies in other organisms, including humans. This article was authored by Shivani Nender, Mark Antwanshak, Wen Wang, and others.