 So on behalf of the many years research laboratory at the University of Sydney and our group leader Aaron camp It is a pleasure to accept this award and we would like to thank all involved with the Brain Foundation But in particular the donors and the sponsors who allow many great research groups within Australia to undertake some Novel and exciting and impactful research in rare and debilitating neurological conditions Such as many as disease this award will allow our laboratory several researchers and research students to undertake a very exciting and novel research project into understanding of the unknown disease process and progression of many as disease and for those who are unaware of what many as disease is it is a Rare and debilitating in a ear disorder, which is characterized by crippling symptoms Which is vertigo tinnitus or ringing within the ear hearing loss and pressure in in their head and within the ear So although these symptoms have been well characterized over the last several decades that there's no clear link between How they result in balanced dysfunction and these debilitating vertigo attacks for the patients So without an understanding of what is occurring in these patients There can't be any clinical progression in terms of developments of treatments and cures So it is our hope to undertake some some novel research on a biomarker or an indicator on many as disease which is something called Endolymphatic hydrops and and this is a swelling or a bloating in the inner ear Which is a build-up of the inner ear for the salty fluid called endolymph But unfortunately, it's unknown how this build-up or bloating of the inner ear fluid actually occurs in these patients So we're using a novel mouse genetically modified mouse model to try and understand the link between endolymphatic hydrops in many ears disease and the balanced dysfunction and vertigo attacks and we're using a series of New techniques that we've developed developed over the the last five or so years We're using electrophysiology in a several imaging modalities and also behavioral techniques as well it's really zone in on a cascade of changes which are occurring in these mouse This mouse model. So we're the although this probably has Can uncover the unknown disease process of many as disease and balanced dysfunction in endolymphatic hydrops? It may lead to an improved clinical diagnosis and screening of these many as patients and the potential development of novel therapeutics to attenuate and and aid Ceasing this balanced dysfunction in many as disease. So once again, we'd really like to thank the brain foundation for this opportunity