 Emerging SARS-CoV-2 variants contain mutations in the spike protein that may affect vaccine efficacy. Show, using Sarah from 180BNT162B2 vaccinated healthcare workers, that neutralization of SARS-CoV-2 variant B.1.1.7 is not affected, while neutralization of B.1.351 variant is 5-fold reduced. This article was authored by Pinja Jalcanine, Petka Kolmanen, Hanny K. Hakkinen, and others.