 Lung cancer remains a major health issue, despite extensive research into its prevention and treatment. To better understand the disease, researchers have developed a novel lung cancer model using patient-derived tumor spheroids, endothelial cells, and lung tissue scaffolding. The resulting bio-fabricated model mimics the patient's original tumor and can accurately reproduce their response to chemotherapies and targeted drugs. Additionally, this model can be used to identify potential drug targets and provide more accurate predictions of patient outcomes. This article was authored by Mingyu Shai, H.S. Anuan Fong, Kaiwen Kan, and others.