 Amygdalin, Quackery or Cure Amygdalin is a cyanide-containing compound found in apple seeds, but 10 times more concentrated in the seeds of peaches, apricots, and bitter almonds. It can be sold as a derivative called leotryl, advertised with the misnomer vitamin B17. It gained popularity among cancer patients as an alternative treatment in the 1970s. But the reason there's this 2016 review, and the reason I'm doing videos about it, is that it's experienced a renaissance thanks to the internet. Back then, all the FDA could do was send out a bulletin to a million doctors and other health professionals warning them that leotryl is not only worthless, but dangerous. 10,000 copies were made for posting in post offices. The New York Times editorialized that people should be able to choose their own placebo, but the stuff was killing people. Finally, as the New England Journal of Medicine reported it, the Supreme Court stops the nonsense, with Thurgood Marshall writing the unanimous court opinion that terminally ill patients deserve the same FDA protections against unsafe drugs, and it was banned on a federal level. Rational argument failed to dissuade people, and so the state stepped in. But that had the opposite effect with cancer victims and their families accusing the government and mainstream medicine of a grand conspiracy. An FDA meeting, for example, an MD Anderson doc rhetorically asked, surely you can't believe that the quarter of a million American physicians are sitting on a cancer cure just so they can get rich. He was answered with a chorus of yeses from the audience. Who was getting rich were some of the leotryl advocates, like the head of the Committee for Freedom of Choice in Cancer Therapy, committed to the freedom of pocketing millions a year in leotryl sales. Those proponents consider it to be a natural cancer cure, whereas opponents consider it the slickest, most sophisticated, and certainly the most remunerative, the most lucrative, profitable cancer quack promotion in medical history. But you don't know which until you put it to the test. The National Cancer Institute, in response to widespread public interest, undertook a retrospective analysis of leotryl treatment. In other words, they sent a letter out to every physician in the country, plus tens of thousands of other health professionals, contacted all the pro-leotryl groups, and basically said, look, send us the best you got. Although it's estimated that at least 70,000 Americans had used this stuff, only 93 cases were submitted for evaluation. And of those, only six appeared to be legit, where taking leotryl was associated with at least some partial improvement. Now of course, the people sending in those reports may have gotten things wrong or just made stuff up, falsified data. But hey, maybe those six actually did respond to the treatment. If that's out of 70,000 treated, though, you'd think maybe that'd just be by chance. But hey, the fact that so many people tried it should count for something. Yes, they may have all just been boondoggled, but maybe there's something to it. Certainly the fact that it didn't seem to help within the laboratory and what cancers doesn't mean it still couldn't work in people, the only way to know for sure is to put it to the test. A clinical trial performed incompetent and experienced hands. The Mayo Clinic accepted the challenge. 178 cancer patients were treated with it and all the patients died rapidly. No substantive benefit was observed in terms of cure, improvement, or even stabilization of cancer, nor improvement of symptoms, nor extensiveness of lifespan, only adverse effects of cyanide toxicity. Conclusion, amygdala and leitral is a toxic drug that is not effective as a cancer treatment. The books then were closed on it for more than 30 years. Leitral doesn't work unsafe and ineffective. No sound evidence that leitral is effective as an anti-cancer agent. So the label unproven cancer remedy may be too generous at this point. It's time to vehemently assert that leitral cancer therapy has been disproven.