 This study aimed to develop a definition of indigenous strengths-based health and wellness research. It involved three phases. First, participants provided 218 unique responses to the focus prompt. Second, they sorted statements into groupings and named them. Third, two virtual meetings were held to share and discuss the results. Six clusters emerged from the data which represented the meaning of indigenous strengths-based health and wellness research. All six clusters were rated as moderately important. The study concluded that this framework offers actionable steps for researchers, public health practitioners, funders and institutions to promote relational, strengths-based research that has the potential to promote indigenous health and wellness at individual, family, community and population levels. This article was authored by Victoria M. O'Keefe, Tara L. Maudry, Ashley B. Cole and others.