 Abstract intervertebral disc degeneration, IVDD, induced lower back pain, LBP, is caused by feroptosis, which is partially attributed to the gene expression data found in the gene expression omnibus, GEO, database. Polydopamine nanoparticles, PDAN piece, were used to treat IVDD induced LBP in vitro, as they scavenged ROS, chelated Phe2 plus to reduce iron overload, and regulated the expression of iron storage proteins like ferritin heavy chain, FHC, ferritin, and transferrin receptor, TFR. Additionally, PDAN piece co-localized with glutathione peroxidase 4, GPX4, around the mitochondria and suppressed ubiquitin, mediated degradation, which prevented phospholipid hydroperoxides from forming and thereby reducing feroptosis. Furthermore, PDAN piece also reduced MDA in lipid peroxide, LPO, levels, which are indicators of oxidative stress and protected against puncture induced degeneration in. This article was authored by Xiaoyang, Yan Chen, Jiao Donghua, and others. We are article.tv, links in the description below.