 The present study explores the human papillomavirus-associated cervical cancer and DNA polymerase-theta inhibitor properties of several epigenin derivatives through in silico analyses, including molecular docking, molecular dynamics, QSAR, drug likeness, PCA, dynamic cross-correlation matrix, and quantum calculations. The study reveals promising energy-binding interactions between all epigenin derivatives and the targeted proteins, with epigenin for Olu ramnicide and epigenin for alpha-rel, ramnicide demonstrating higher potency against HPV45 on coprotin E7. The findings are further validated through molecular dynamic simulation for 100 nanoseconds, and the compounds undergo screening for admet, pharmacokinetics, and drug likeness properties. However, additional wet lab experiments should be conducted to confirm the findings. This article was authored by Shobnil Akash in Renbeil, M.D. Saddam Hossein, and others. We are article.tv, links in the description below.