 This study investigated how the spatial organization of pyruvate dehydrogenase kinase, PDK1, activity in coal and tumours affects their metabolism and drug sensitivity. It found that PDK1 activity is concentrated in certain areas of the tumour, forming a spotted pattern. This pattern is predicted to be caused by the WNT signalling pathway, which is known to promote Warburg metabolism and tumour growth. Inhibiting WNT signalling decreases the size and intensity of the spots, suggesting that it plays a role in the formation of these regions. Additionally, the researchers found that inhibiting both WNT signalling and glycolysis together could lead to greater efficacy than either treatment alone. This article was authored by Mary Lee, George T. Chen, Eric Putik, and others.