 What comes to nursing school explained in this video on creatinine clearance? Really this topic fits into both Playlists, which is the laboratory values as well as the pharmacology playlists and it is Evaluated because we want to know what the patient's kidney function is in general the creatinine clearance reference range is 85 to 135 Milliliters per minute, but as always make sure that you know the reference range for the lab that you're working with So that you know if your patient's values are inside or outside the normal values And so as a quick review creatinine is the byproduct of protein Metabolism and I have a separate video that goes over that specific lab test and is therefore an indicator of renal function and The clearance of the creatinine depends when we're talking about clearing the medications out of the patient system on the volume of the Medication distributed throughout the patient's body as well as the medication half-life Please check out my other video on half-life where I go more into explaining that and here is the formula and you won't have to remember this I just want to make sure that I Mention this before we go into the formula I also want to point out that over here as the patient's age increases Typically elderly patients have lower muscle mass and their clearance will also be lower And this comes into account when we look at the formula here so the creatinine clearance equals in the numerator a 140 minus the patient's age in years and then that number gets multiplied by the ideal body weight in Kilograms and divided by the serum creatinine multiplied by 72 to give us the creatinine clearance now the best test to diagnose How much creatinine is really being cleared by the kidneys? How much is actually leaving the patient's body is a 24-hour urine where we actually collect the urine for 24 hours and then Look at how much creatinine is in there and those two tests are usually used in conjunction mostly by the pharmacologist by the pharmacist to Determine the patient's renal function if they are getting nephrotoxic medications such as the antibiotics in the mycine Categories such as Tobromycin, Gentamycin and those kind of things chemotherapy agent and some really caustic Medications that can have a big harmful effect or could have a harmful effect on the kidneys and Adjustments in this formula can also be made for patients with renal disease so when do we check creatinine clearance is when we have a patient with any acute or chronic renal disorders and that ranges from a kidney stone to Robdomyolysis to chronic end-stage renal disease So anything that has to do with the kidneys the creatinine clearance is good for We also check it before we administer nephrotoxic drugs and also during that treatment To evaluate the glomerular filtration rate and also monitor the treatment for renal disease The patient is receiving so we can see how these drugs or whatever else is affecting the patients kidneys So thanks for watching this video on the creatinine clearance also check out the other videos in the pharmacology as well as the Laboratory value playlist so that you get a better understanding and see how they all play together Thanks for watching. See you soon