 The study investigates the potential for vertical DNA transmission from maternal endometrial EVs to pre-implantation embryos and its impact on embryo-bioenergetics, discovering that MBs contain significantly higher levels of MT DNA during implantation, which is internalized by trafoblast cells, leading to a reduction in mitochondrial respiration and ATP production. This article was authored by David Bolumar, Javier Moncaio-Alandi, Javier Gonzalez-Fernandez, and others.