 Abstract Paroxynase II, PON2, is a multifunctional intracellular enzyme that has been shown to have anti-cancer properties. This study examined the effect of PON2 on lung cancer cell proliferation and lung tumoragesis in mice. The results showed that PON2 expression deficiency hampered the proliferation of cultured lung cancer cells with concomitant cell cycle arrest at the G1 phase. Additionally, PON2 expression deficiency also impaired key aspects of oxidative metabolism in lung adenocarcinoma cells. Furthermore, the lack of PON2 did not affect the development of subcutaneous or orthotopic LLC tumors, nor did it alter the frequency of tumor infiltrating myeloid subsets including MDSCs and tumor associated macrophages. These findings suggest that PON2 does not play a major role in murine lung tumoragesis. This article was authored by Aaron G. Witt, Aaron M. Neely, Omar Sadi Saka and others. We are article.tv, links in the description below.