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Effects of Air Pollution on Immune Function and Asthma

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Published on Jun 7, 2012

Dr. .JOHN BALMES of the Berkeley/Stanford Center for Children's Environmental Health shows that polycyclic aromatic hydrocarbons (PAHs) in air contribute to allergy and asthma in children. PAHs reduce the production of proteins that are important to regulating immune response. PAHs set markers through epigenetic methylation that reduce the expression of a gene known as Foxp3. This leads to more asthma, reduced lung function, and greater wheezing.

This was part of a symposium organized by the Office of Environmental Health Hazard Assessment of Cal/EPA http://oehha.ca.gov/index.html, the Pediatric Environmental Health Specialty Unit at UCSF http://coeh.berkeley.edu/ucpehsu, and the Center for Integrative Research on Childhood Leukemia and the Environment at the University of California Berkeley http://circle.berkeley.edu. Research funding is from the National Institute of Environmental Health Sciences and the US EPA. Presentations do not represent the views of these agencies.

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