 Mycotoxins are harmful secondary metabolites produced by fungi that can cause serious health problems in animals and humans. These contaminants have been shown to impair growth, weaken immune systems, and lead to liver and kidney damage or death. While the impact of mycotoxins on intestinal functions is less well understood, recent research has demonstrated that these fungal metabolites can compromise key gastrointestinal functions such as nutrient absorption, transporter activity, and barrier function. Additionally, some mycotoxins have been linked to the persistence of intestinal pathogens and inflammation. This review focuses on three commonly occurring and toxic mycotoxins, aflatoxins, octatoxin A, and fusarium toxins. The analysis includes nearly 100 published experiments that examine the effects of these toxins in vitro, ex vivo, and in vivo at varying doses. This article was authored by Todd J. Applegate and Bertrand Grainier. We are article.tv, links in the description below.