 This article discusses the use of extracellular polymeric substances, EPS, released by microorganisms as a potential solution for heavy metal contamination remediation. EPS is composed of proteins, polysaccharides, and other biopolymers and has net anionic properties that allow it to effectively sequester positively charged heavy metal ions. The article explores current research on the biosynthesis and heavy metal sorption abilities of EPS in various forms, including mixed culture EPS, single cell EPS, live, dead, or immobilized EPS. However, challenges remain in commercialization due to factors such as scalability and cost effectiveness. Despite these challenges, the article highlights the potential of EPS for sustainable and eco-friendly biode toxification of heavy metal contaminated terrestrial and aquatic systems. This article was authored by Pratima Gupta and Batool Dewan.