 Infection with SARS-CoV-2 and the development of coronavirus disease 2019, COVID-19, has been linked to induction of autoimmunity and autoantibody production. Here the authors characterize the new-onset IgG autoantibody response in hospitalized patients with COVID-19, which they correlate to the magnitude of the SARS-CoV-2 response. This article was authored by Sarah Esther Chang, Alan Feng, Wen Jiao Meng, and others.