 This study compares the latest cancer profiles, trends, and determinants between China and the United States, USA. In 2022, there will be approximately 4,820,002,370,000 new cancer cases, and 3,210,640,000 cancer deaths in China and the USA, respectively. The most common cancers are lung cancer in China and breast cancer in the USA, and lung cancer is the leading cause of cancer death in both. Eight standardized incidents and mortality rates for lung cancer and colorectal cancer in the USA have decreased significantly recently, but rates of liver cancer have increased slightly. Rates of stomach, liver, and esophageal cancer decreased gradually in China, but rates have increased for colorectal cancer in the whole population, prostate cancer in men, and other seven cancer types in women. Increases in adult population size and population aging were major determinants for incremental cancer deaths, and case fatality rates contributed to reduced cancer deaths in both countries. The decreasing cancer burden in liver, stomach, and esophagus, an increasing burden in lung, colorectum, breast, and prostate, mean that cancer profiles in China and the USA are converging. Population aging is a growing determinant of incremental cancer burden. Progress in cancer prevention and care in the USA, and measures to actively respond to population aging, may help China to reduce the cancer burden. This article was authored by Chiang Fuxia, Xu Sidong, He Li, and others. We are article.tv, links in the description below.