 This study examined the effects of heat and drought stress on berries from two wine great varieties. It found that heat and drought stress have a greater effect on berry metabolite levels than water stress. Additionally, it discovered that heat stress has a greater effect on gene expression than water stress in both varieties. This knowledge can be used to develop strategies for mitigating the effects of climate change on great production. This article was authored by Shauna Hewitt, Esther Hernandez-Mantes, Amit Dhingra, and others.