 calcium phosphate ceramics are commonly used in orthopedics, dentistry, and maxillofacial surgeries as bone replacements and regenerations. The success of these treatments depends on the ability of the ceramic to degrade and be replaced with new bone tissue. This process involves several different cell types, including macrophages, fibroblasts, osteoblasts, and osteoclasts, which all play a role in the degradation of the ceramic material. Macrophages and fibroblasts secrete cytokines and other growth factors that stimulate the production of osteoclasts, while osteoclasts break down the ceramic material. Additionally, the pH level of the environment can also influence the rate at which the ceramic material degrades. This article was authored by Zishan Sheikh, Mohamed Nair Abdullah, Ahmed Abdullah Hanafi, and others.