 I am myself Raul Savan, 3rd year radiology resident at G.S. Medical College in K.M. Hospital, Mumbai. And my topic for paper presentation is Ardhan Chastra disease, a case report. Introduction. Ardhan Chastra disease is a rare non-language histrocytic disorder with multi-system involvement. It's peak incidence in the 5 to 6 decades of life and slightly more common ailments although children can be affected. The etiopathogenesis of this disease is unclear and it is postulated that the Ardhan Chastra disease could arise due to the immune mediated phenomenon resulting from the exaggerated proliferation of alpha T cells resulting in the release of pro-inflammatory cytokines like interferones that further leads to the recruitment and activation of the mast cells at the site of involvement. Ardhan Chastra disease usually presents with non-specific symptoms. Often the symptoms depends on the site of involvement and the common constitutional symptoms of the Ardhan Chastra disease are like fever, bed loss, night sweats could be mistaken for the tuberculosis. Most common presenting symptoms is the bone pain as the skeletal system is the most often affected. The classical trial of Ardhan Chastra disease includes the bone pain, central diabetes inhibitors and bilateral exothermas. Clinical, radiological and light microscope findings are usually similar and indistinguishable from the Langerhansel histrocytosis. Histopathologically in Ardhan Chastra disease, the tissue is inflicted with the Liffried Leiden histrocytes. Ardhan Chastra disease can be distinguished from the Langerhansel histrocytosis by the demonstration of CD68 positivity in such Xanthobranilometous histrocytic infiltrates with the lack of CD1A and Birbeck granules. A case, a 50 year old woman came with complaint of decreased in vision in both eyes, which was in series in one set gradually progressive over six months. It is associated with mild to morbid headache. Patient also complains of non-specific pain in both knees for the past two to three years for which never got investigated. C is not known case of chronic illness and her family history was uneventful. For above complains the patient was reported to ophthalmologist on examination. There was a process of both eyes with decreased visual accuracy not associated with the condition or painful restriction of movement based on the above findings of ophthalmologist advice MRI blade and MRI brain plane plus contours were done which is a T1 hypointense homogenously enhancing T1 or T1 hypointense T2 iso intense homogenously enhancing legion in the cellar and supra cellar region compressing the pituitary against the cellar. The legion is seen in involving both the cavernous sinuses with encasement of supraclineoid and cavernous segment of both the ICA. The posterior legion is seen extending into the clivus and the pre-pontine system causing encasement of the basilar top anteriorly the legion is seen extending into superior and medial extended intraconal compartments of the both the orbits through the superior orbital fissure. Superarily the legion is seen compressing the optic no and caesma optic caesma. The patient is further instigated and the CACD chest and abdomen was done which shows the homogenously enhancing soft tissue encasing the outer till its bifurcation till its bifurcation giving coated outer appearance with loss of fat plane without equal homogenously enhancing soft tissue with surrounding ground glassing is seen in the misentry enrolling the misentry route and encasing the superior and infiric misentry artery origin and its branches encasement of the left renal vein is also seen X-ray bilateral knee was done which shows multiple tiny varying size clerotic foci in the proximal epiphysis and metaphysic of both tibia and also in the metaphysic of distal end of fume. Now histopathology with immunochemistry findings the specimen biopsy was taken from the cellular legion on gross examination the greyish white soft tissue is there and the microscopy the legion composed of silts of homo xanthomatous cells interfaced with the occasional multi-nucleotide like admixt small aggregates of reactive lymph nodes lymphocytes no mitosis identified. Langer and cell histocytosis versus other intestine disease was suspected the immunochemistry findings suggest of CD68 and CD163 positive CD1N is 100 negative above findings of non-language cell histocytosis the diagnosis final diagnosis was made other than chest disease discussion other than chest disease is a rare disease first reported in 1930 it is a rare form of non-language cell histocytosis the pathogenesis of disease is inflatation of multi-systemic organs and bones by foamy microphages multi-nucleotide G-ansel and inflammatory cells most commonly affecting the fifth decade with slightly common in males presenting symptoms are non-specific most common in all system is the skeletal system the radiological findings are the bilateral symmetrical metaphysal and dysphysal sclerotic lesion in skeletal system and the cortical thickening intracranial enrollment the x-axis enhancing soft tissue mimic the meningoma in some cases pituitary and infundibular enrollment is common presenting with diabetes incipidus intraparenchymal enrollment is non-specific orbital enrollment retroorbital masses causing proptosis and modality impairment the soft tissue can extend along the reticulum causing optic edema kidneys and retroperitoneum irregular and symmetric involvement of bilateral peri-renal and posterior parallel space giving hairy kidney apparatus periodic soft tissue giving coated sign inferior vena cava inhibitors are typically spared which helps in differentiating it from the retroperitoneum fibrosis and in chest the symmetric reticular interstitial opacities and smooth interlobular septal thickening pleural effusions multifocal thickening with effusion is seen differential diagnosis include the depending on the involvement of systems which system depending on the system involved first is IZG4 a related multi-systemic infiltration is the closest differential Langerhansel histocytosis in bone and chest involvement and the retroperitone fibrosis and lymphomind retroperitoneum these are the references thank you thank you thank you