 This study reveals that SCHLAP1 is an oncogene in non-small cell lung cancer, NSELC, and promotes cancer cell immunovasion by regulating the AUF1-PDL1 axis. Targeting of SCHLAP1 may be a potential approach to improve the efficacy of immunotherapy in NSELC patients. This article was authored by Zheng Haidu, Xu Xiannyou, Huang Wang, and others.