 Obesity surgery can lead to significant weight loss and improved blood sugar control. This is due to changes in gut hormones such as glucagon-like Peptid-1, GLP-1, which are regulated by the GLP-1 receptor, GLP-1R. Two Peptids, GEP44 and GEP12, have been found to activate this receptor and increase insulin production, leading to better blood sugar control. Additionally, these Peptids can reduce appetite and promote fat burning, making them promising candidates for treating obesity. This article was authored by Kylie Estetua, Clinton T. Elfis, Therese Salome and others.