 This study developed a novel pH-responsive nanocomposite consisting of chitosan, montmorillonite, nitrogen-doaked carbon-quantum dots, and doxorubicin for targeted delivery of the anti-cancer drug. The incorporated nanoparticles increased the loading and entrapment efficiency of the drug, resulting in an extended pH-responsive release of the drug over a period of 96 hours. This pH-responsive nanocomposite also showed reduced cytotoxicity and induced more apoptosis in cancer cells compared to free doxorubicin or the chitosan montmorillonite doxorubicin nanocarrier. This article was authored by Irfan Ramani, Mairabh Pormadadi, Saurabh Ali Gorbanian, and others.