 Nuclear receptors are proteins that regulate gene expression when they bind to specific DNA sequences. They can be activated or inactivated depending on the type of ligand that binds to them. In this study, researchers found that certain ligands can activate a particular nuclear receptor called NR4A2NR2B1, which is known as NER1RXR. This activation is achieved through a unique mechanism involving the binding of two different types of ligands to the same receptor. The first ligand binds to the receptor's ligand binding domain, while the second ligand binds to the receptor's protein-protein interaction site. By doing so, it weakens the bond between the two subunits of the receptor, allowing the monomer form of the receptor to escape and activate transcription. This novel mechanism of action provides a new understanding of how these ligands work and could lead to the development of drugs that target this pathway. This article was authored by C.O.U.U., Jin Saishong, and Douglas J. Cojatin. We are article.tv, links in the description below.