 Stigma and discrimination are major barriers to accessing quality sexual and reproductive health services. This systematic review and narrative synthesis examined existing strategies to reduce stigma and discrimination in these settings. The authors found that most studies focused on quantitative measures such as knowledge and attitudes while few evaluated actual behavior change. Qualitative studies revealed positive experiences among health workers after implementing stigma reduction strategies. The authors also noted that stigma reduction efforts must target multiple levels of stigma including individual, organizational, and societal levels. They recommended further research into the effectiveness of stigma reduction strategies as well as the development of more comprehensive evaluation methods. This article was authored by Megan A. Boren, Martha Vasquez-Corona, Osamudim J. Odias and others.