O Brother, Where Art Thou? Trailer - Directed by Joel Coen and Ethan Coen and starring George Clooney John Turturro Tim Blake Nelson John Goodman and Holly Hunter O'Brother, Where Art Thou? Is a Coen Brother's film roughly based on Homer's "Odyssey." Taking place in the deep south in the 1930's the film tells the story of three escaped prison workers and their journey for a buried treasure. On their journey they come across many comical characters and incredible situations.