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Mitotic Spindle and Cell Cycle, Rate My Science

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Published on Oct 15, 2008

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Prostate-specific membrane antigen (PSMA, NAAG Peptidase, FOLH1) is localized in the vicinity of mitotic spindle poles and associates with the anaphase-promoting complex (APC).
Mol Cancer Ther. 2008 Jul;7(7):2142-51.
PSMA-expressing cells prematurely degrade cyclin B and exit mitosis due to increased APC activity and incomplete inactivation of APC by the spindle assembly checkpoint.

The cell cycle, or cell-division cycle, is the series of events that take place in a eukaryotic cell leading to its replication. These events can be divided in two brief periods: interphase—during which the cell grows, accumulating nutrients needed for mitosis and duplicating its DNA—and the mitotic (M) phase, during which the cell splits itself into two distinct cells, often called "daughter cells".

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