 Thanks, David, and thanks to the Brain Foundation. So David didn't tell you the topic of our research project. Our goal is to develop a new treatment for brain AVMs. And these are collections of abnormal blood vessels that sit inside the brain. And people don't know that they have them until they burst. And when they burst, they cause a hemorrhage bleeding into the brain, which is catastrophic. It either kills the person or causes that type of stroke. And this happens particularly in children and young adults. So it's not a typical type of stroke that you might think of that generally affects older people. It's a young person's disease. And we can treat these things with surgery in some of the patients. But for patients who have large malformations or deep ones, surgery is too dangerous. So we've got this idea that we can treat them with a two-step process. The first step is to use focused radiation, such as the gamma knife, where we focus all the radiation beams into the volume of abnormal blood vessels. And it's like painting a molecular change. So all the cells within that volume will change their molecular characteristics. And then we can inject into the systemic blood circulation an agent that will target those molecular changes and then induce blood clots within those abnormal vessels. So unlike the rest of the world who's trying to prevent blood clots, we're actually trying to cause blood clots to block off these abnormal blood vessels. We've actually had a lot of success in the laboratory. We've shown that we can do this in our animal model in the laboratory and completely cure AVMs using this technique. But before taking it to the clinic, we want to make absolutely sure that we've got the best technique available. And at the moment, we're using a single molecule construct. So our systemic agent that we've developed is an antibody connected to a molecule that promotes blood clotting in the blood vessels. But it's a single molecule. So the idea of this project is that we think using nanotechnology, developing artificial cells, if you like, that can carry instead of a single molecule, hundreds or perhaps thousands of these targeting molecules that we'll then collect in the abnormal blood vessels could really amplify the response and make this a much more effective treatment. The gift from the Bain Foundation is really crucial for us to develop the early stages of that work and see if we can develop this technology to be at least as effective as the single molecule approach and hopefully to be more effective. So it's a really important contribution and thanks very much again for the support.