 This study examined the impact of the COVID-19 pandemic on clinical research units, CRU. It found that the majority of crews had to make significant adjustments to their daily operations due to the pandemic. These included virtual visits, adapting to new protocols, and playing a major role in administering and supporting both COVID-19 therapeutic and vaccine trials. Additionally, the study identified several best practices that crews can use to help navigate the pandemic. These include having a plan in place for virtual visits, adapting to new protocols, and playing a major role in administering and supporting both COVID-19 therapeutic and vaccine trials. This article was authored by Moran Subramain, Jacqueline M. Wandaveri, Kimberly J. Sprenger, and others.