 Collaging is a major component of the tumor microenvironment and plays a crucial role in cancer fibrosis, with its biosynthesis regulated by cancer cells through various mechanisms. Collaging influences tumor cell behavior through integrins, discoid endomain receptors, tyrosine kinase receptors, and signaling pathways. Exosomes and microRNAs are closely associated with collaging in cancer. Hypoxia intensifies cancer progression, and other extracellular matrix substances interact with collaging to influence cancer cell activity. Macrophages, lymphocytes, and fibroblasts play a role with collaging in cancer immunity and progression. Changes in collaging content within cancer cells and matrix cells contribute to a feedback loop that influences prognosis, recurrence, and resistance in cancer. Nanoparticles, nanoplatforms, and nanoenzymes exhibit promising therapeutic options for diverse cancers, and the emerging understanding of collaging structural properties and functions will guide the development of new strategies for anticancer therapy. This article was authored by Shu Aishu Aishu, Wenquan Wang, and others. We are article.tv, links in the description below.