 Smeducin-6 is a novel membrane-tethered palmitic acid conjugate of SMAT-6, which targets Pelino-1 protein in the TLR4 signaling pathway. This compound has been shown to be effective in treating sepsis, CLP-induced sepsis, and LPS-induced endotoxemia. This article was authored by Eun Suk Lee, Jin Suk Park, Soo Myung Jung, and others.